![]() Atezolizumab, in combination with the chemotherapy drug nab-paclitaxel, may be an option for women with previously untreated locally advanced or secondary triple negative breast cancer. Also known as Tecentriq, this drug targets a receptor called PD-L1 which is found in triple negative breast cancer. The National Institute for Health and Care Excellence (NICE) – who decide which medicines will be available on the NHS in England – is currently considering a new treatment for triple negative breast cancer called atezolizumab. Are there any new drugs for triple negative in the pipeline? Because chemotherapy is not as targeted as drugs like trastuzumab and tamoxifen, it can cause significantly more side effects. Treatment for triple negative breast cancer is therefore limited to surgery, radiotherapy and chemotherapy. Because triple negative cancers lack receptors, it’s not possible to treat them using targeted drugs like these. For example, the drug trastuzumab kills breast cancer cells by latching onto the HER2 receptor, while tamoxifen works by blocking the oestrogen receptor and stopping oestrogen from stimulating breast cancer cells. Many of the most effective breast cancer treatments work by targeting receptors. Why is triple negative breast cancer harder to treat? For example, the hormone oestrogen stimulates the growth of some breast cancer cells through the oestrogen receptor.Īround 15% of all breast cancers – over 8,000 cases a year in the UK – are triple negative. ![]() These receptors are important for passing signals to cancer cells. All other types of breast cancer have at least one of three receptors: the oestrogen receptor (ER), progesterone receptor (PR), or human epidermal growth factor receptor 2 (HER2). It’s known as triple negative because it lacks three molecules called receptors. Triple negative breast cancer is a relatively uncommon form of breast cancer that is usually more aggressive and harder to treat than other types of breast cancer. Here's everything you need to know about the basics. Triple negative breast cancer is not very common, and many people have not heard of it before. Across the board, there is still lot we don't know about breast cancer. ![]()
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